USC vs. Michigan game odds, picks for Week 4

One of the Big Ten's new-look conference games kicks off this week as No. 11 USC hits the road against No. 18 Michigan in one of college football realignment's new rivalry games on Saturday.

Michigan sits at 2-1, still reeling from the loss at home to Texas two weeks ago and hoping to avoid falling to .500 just nine months after winning the national championship.

USC is 2-0 and boasts a statement win against a ranked LSU in the season opener, an important redemption moment for head coach Lincoln Riley and a positive early preview for this defense.

Let's take a look at what the oddsmakers predict for USC vs. Michigan in this Week 4 football game.

USC vs. Michigan game odds, picks

USC is a 5.5 point favorite against Michigan, according to the lines at FanDuel Sportsbook, which set the total at 46.5 points for the game.

Michigan has won its last 20 games straight-up against Big Ten teams.

USC: -5.5 (-110)
Michigan: +5.5 (-110)

Over 46.5 points: -115
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USC vs. Michigan trends

USC is a perfect 2-0 against the spread this season ...

USC is a perfect 2-0 against the spread this season ...

Michigan: +5.5 -110 ...

Michigan is 9-4 against the spread in its last 13 games as the favorite ...

The total went over in 7 of the Trojans' last 8 games on the road ...

The total went under in 4 of Michigan's last 6 games ...

When: Sat., Sept. 21 ...

Michigan has won its last 20 games straight-up against Big Ten teams ...

Spread consensus picks

The vast majority of bets predict that USC will handle its business against Michigan this week.

TV: CBS network.

TV: CBS network.

Our pick: USC -5.5

USC vs. Michigan schedule

Michigan is 9-4 against the spread in its last 13 games as the favorite
Sep 16, 2024
TV: CBS network

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Oddsmakers reveal their prediction for USC vs. Michigan in this Week 4 college football game.

USC is a perfect 2-0 against the spread this season.

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TV: CBS network: When: Sat., Sept. 21 | Schedule | Teams

FanDuel lists the moneyline odds for USC at -225 and for Michigan at +190 to win outright: Bookmark | Rankings | Picks